ChemDiv chemistry of cures

For over 20 years ChemDiv is helping its clients to discover and develop novel medicine to treat viral and other infectious diseases.

Since 2007, we offer fully integrated anti-infective programs, combining both chemistry and biology support.  Each program is run by a team of very experienced, US- and Western Europe-trained medicinal chemists, virologists and biologist, lead by seasoned pharmaceutical professionals. Program management is located in the US, facilitating efficient communication with the client.

We use our proprietary extensive and diverse library of chemical compounds, medicinal chemistry prowess, rational and structure-based drug design and chemical informatics capabilities to rapidly apply these technologies to novel targets to identify lead compounds for further development. Antiviral assays routinely run in-house include a vide arsenal of top-notch contemporary molecular virology and molecular biology, such as the real-time RT-qPCR-based in-vitro infection and viral replicon assays for  HCV, HIV, HBV, Human Influenza, Yellow Fever, Dengue Virus, West Nile Virus etc.

Wide range of anti-viral assays and comprehensive experimental platforms are put together to provide the combinations of the following services:

• Assays and Screening approach to high throughput hit hunting benefits from the application of focused discovery subsets of the 1.5 million small molecules in ChemDiv's proprietary discovery inventory. These are subjected to well-defined assay and high and medium throughput screening platforms to identify and confirm compounds which serve as starting points for medicinal chemistry lead optimization.
• Anti-viral activity determination
• Compound profiling
• Cytotoxicity evaluation
• Invarious mammalian cell lines and primary cell cultures
• SAR activity
• Drug-drug interaction studies
• Drug resistance and cross-resistance studies
• Drug combination studies
• Hit-to-lead expansion
• Lead generation and clinical candidate selection

Please visit case studies page to view the examples of our current developments:

See Also:

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HCV
HBV
HIV
Influenza