METABOLIC CHEMICAL LIBRARIES and BIOLOGICAL ASSAYS
Metabolic diseases-related chemical libraries are designed to simplify the very difficult task of identification and development of successful small molecule drugs. Complexity of identified targets, need for more targets, high level toxicity and ADME requirements associated with this area of research are what catalyze ChemDiv's involvement in Metabolic diseases. Several comprehensive approaches have been employed for the design, synthesis and selection of proposed libraries: development of peptidomimetics, analysis of a specific disease's "targetscape" and selection of appropriate prototypes for virtual screening exercise, neural networks scaffolds sorting, and others. With new chemical libraries, ChemDiv offers excellent chemical starting points for discovery applications and follow-up development. ChemDiv is constantly updating its chemical libraries and biological assays for metabolic diseases. The following are examples of capabilities:
Libraries List:
- AcetylCo library
- Alpha2-Adrenoceptor Antagonists
- Arginine Kinase library
- Bradykinin library
- CB1/2 library
- Cl- channels library
- FSH agonists library
- Glucokinase activators library
- Na+ channels library
- nAChR library
- Phosphatases library
- Purinergic library
- RAR library
- Secretase library
- Steroids/steroid-like library
- Transporter inhibitors library
DIABETES/OBESITY RELATED ASSAYS INCLUDE:
- GPCRs agonists/antagonists (FLIPR-based technology, LANCE cAMPAssay-PerkinElmer)
- Kinase assays (ADP Hunter, ELISA)
- Enzyme
 See Also:
Metabolic In Vivo
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Pre-Clinical Development 
