CNS CHEMICAL LIBRARIES and BIOLOGICAL ASSAYS
Design and synthesis for known drugable and novel targets are an important and difficult task. ChemDiv offers the platform approach to designing the diversity of useful synthetic arrays implementing them as discovery tools for a large number of CNS relevant biotargets and pathways. Each chemical library, i.e. discovery tool, is projected from a unique design and synthesis methodology depending on relevance and availability of target, ligand and function information. Proprietary innovative discovery tools have successfully achieved lead and drug candidate milestones for our collaborators. ChemDiv synthesizes more than 200,000 new chemical entities each year and is constantly adding biological assay and animal model capabilities.
Examples of the libraries:Apoptosis
- Modulators of proliferation and differentiators of stem cells
- Transporter inhibitors library
- GABA (A) library
- mGluR ligands
- Citokine library
- HDAC library
- HSP90 library
- K+ channels library
- GSK3b library
- Methyltransferase inhibitors library
- MK2 inhibitors library
- Na+ channels library
- nAChR libraryPDZ library
- Phosphatases library
- Purinergic library
- Secretase library
- Serine/Cysteine Proteases inhibitors library
- GPCR platform se
- Ion Channels platform set
- Kinases platform set
- Signaling and developmental pathway modulators
- Peptidomimetics
- Natural-like
 See Also:
CNS In Vivo
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