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CNS In Vivo are designed in small animals (rats and mice) and large animal (monkeys) with the objective of providing mechanistic insights into neurodegenerative and psychiatric disease and opportunities for new strategies of therapeutic intervention. ChemDiv adheres to "Good Laboratory Practice" standards to ensure reliability and reproducibility of study results. QC/QA systems encompass SOPs for: study systems, performance, management; handling and analysis of the test items, data and biometrics; confidentiality, identity and security of proprietary compounds and reporting. Unimpaired laboratory animals are required to gain reliable results from behavioral pharmacology. Our quality management therefore focuses in particular on correct animal housing and handling for animal wellbeing, appropriate behavior and generation of valid data
Examples of tests:
The following tests are run routinely and are fully validated. Many additional models can be provided on request:
- General Behavior
- Memory Impairment tests
- Learning & Memory with Aged Animals
- Anxiety & Fear
- Psychomotor Behavior & Coordination
- Depression
- CNS-mediated Eating Disorders. Obesity.
- Drug Abuse & Dependence
- Alcohol and Drug Addiction
- Anti-depressant Activity Tests:
- Parkinsonism
General Behavior
- Open field test
- Rota-rod test
- Cross-maze test
Memory Impairment Tests
- Water maze test (Morris test)
- Passive avoidance
- Novel object recognition test
Learning & Memory with Aged Animals
- Radial Arm Maze
- Morris Water Maze
Anxiety & Fear
- Elevated Plus Maze
- Shock Probe
- Holeboard
- Light / Dark Box
- Passive Shock Avoidance
Psychomotor Behavior & Coordination
- Excitation & Sedation
- Exploration
- Stereotype Behavior
- Rotarod
- Catalepsy Test
- Acoustic startle response test
- Tilt Plane / Righting Reflex
Depression
Basic Pharmacology & Physiology
CNS-mediated Eating Disorders. Obesity
- Irwin Test
- Blood Samples
- Metabolic Cages
Drug Abuse & Dependence
- Withdrawal
- Conditioned Place Preference
Alcohol and Drug Addiction
- Animal Models for Addiction Development
- Loss of Control
- Craving
Anti-depressant Activity Tests
- Porsolt forced swim test
- Tail suspension test
- Elevated platform
Parkinsonism
MPTP-induced motor impairment model
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