ChemDiv chemistry of cures

ChemDiv - Nerviano Partnership

ChemDiv - Nerviano MS successful collaboration was a hit-to-lead optimization campaign of previously discovered through HTS active molecules. The goal of the program was development of Lead compounds with confirmed efficacy in animal models (POC). The collaboration plan included chemistry optimization, in vitro biology, in vitro and in vivo DMPK, efficacy models in animals and comprehensive IP strategy – all of which were successfully executed at ChemDiv facilities. Initially, Nerviano discovered several confirmed hits by screening ChemDiv off-the-shelf collection of small molecules. To move ahead with discovered molecules, Nerviano was looking for a reliable partner who could provide resources to complete the program efficiently and by meeting aggressive deadlines.

Within extremely short period of time (9 months) and through close interactions with Nerviano’s scientists, ChemDiv team managed to rapidly move the compound from Hit level to fully patentable Lead molecules with confirmed efficacy in animals and managed to exceed customers’ expectations in achieving milestones.

This project represents a comprehensible example of harmonious collaboration between partners where ChemDiv demonstrated versatility of research approaches to outstanding challenges and delivered ultimate value to the customer.

About Nerviano MS
Nerviano Medical Sciences is the largest pharmaceutical R&D facility in Italy and one of the largest oncology-focused, integrated discovery and development companies in Europe.