ChemDiv's Drug Discovery - ADME/T (Absorption, Distribution, Metabolism, Excretion and Toxicity)
ChemDiv is a leading provider of ADME/T screening and development programs. We offer standardized and custom programs, led by experienced PhD-level scientific staff, backed up by processes that deliver fast cycle times.
ChemDiv Inc. provides a range of in vitro ADME/T assays to evaluate and improve metabolism, bioavailability, pharmacology, and toxicology characteristics of compounds. Our researchers develop, validate, and apply different modern methods for the early ADME/T testing of potential drugs under development.
- Solubility in Aqueous Solutions (Based on Millipore Multiscreen plates technology).
- PAMPA (Parallel Artificial Membrane Permeability Assay; based on pION PAMPA Explorer technology)
- HSA (Human Serum Albumin) Binding (Based on a displacement of binding site-specific fluorescent dyes).
- Total Plasma Protein Binding
CELL-BASED TOX PROFILING
- Cytotoxic Effects
- Cytostatic Effects
- hERG inhibition
- Cell viability
- Cell growth kinetics
- Apoptosis induction
Biomek 2000, NX, FX work stations with multimode 96/384-well plate readers; Microbeta PLUS 1450 (PerkinElmer), scintillation counters; Victor2V multimode 96/384/1536 plate readers; SpectraMax Plus 96/384 spectral plate readers; pION PAMPA Explorer (GUT Box for Double-sink approach); Harvesters Tomtec Mach III (Tomtec); 96 /384 well format Flow Cytometer.