ChemDiv chemistry of cures

ChemDiv can boast highly skilled synthetic chemistry teams facilitated by a unique collection of synthetic building blocks, proprietary intermediates and modern synthetic chemistry tools. We have a reputation for tackling challenging synthetic projects that have proven intractable for other laboratories. In addition, our teams are guided by medicinal chemistry principles, which altogether have been honed into a valuable system we call Chemistry Systems on Demand. All of this capability is rounded out by scientist project management with close, attentive communication; remaining always focused on the project goals, directions, and progress.

CUSTOM SYNTHESIS

Our highly trained and experienced chemists are ready and able to prepare compounds for you - whether previously described or novel, simple or complex, small scale or large, singletons or libraries. ChemDiv offers clients a variety of advantages, including:

• A rapid assessment of project feasibility, cost and time-frame
• Project management by dedicated chemists
• Proprietary client's target or scaffold-based library design and parallel synthesis (20-2,000 analogs/scaffold)
• Exclusive or semi-exclusive modification of ChemDiv's proprietary library systems
• Proprietary collection of  > 4,000 highly functionalized building blocks
• Development and transfer of protocols and key intermediates
• Material(s) delivery on a 1 mg to 10 kg scale
• Purity to your specifications
• High-throughput H-NMR, LC/MS and purification

EXPERTISE

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ChemDiv's synthetic chemistry expertise includes:

• Heterocyclic chemistry

  • Variety of aromatic and unsaturated N, O, S heterocycles
  • Natural products and natural-like systems including optically active compounds
  • Heterocyclic systems with improved solubility and stability

• Modern organic synthesis techniques

  • Organometallic chemistry: Suzuki, Sonogashira, Heck, Grubbs, Buchwald; large scale Li, Mg, Zn reactions, etc.
  • Microwave-assisted synthesis, both liquid and solid phase
  • Green chemistry
  • High throughput analysis (LCMS, HPLC, multi-nuclear NMR)
  • High throughput purification (HPLC, mass-directed HPLC, SPE, UV FPLC)

• Solid support chemistry

  • 10-10,000 compound parallel synthesis
  • Solid-phase catalysts, scavenger resins
  • Gram scale solid phase synthesis

• Optically active materials

  • Asymmetric synthesis
  • Enantiomers and diastereomers separation and identification
  • Analysis and purification (chiral HPLC, optical rotation, LSR)
  • Absolute and relative stereochemistry assignment (X-ray)
  • peptidomimetics and unusual amino acids and derivatives

• Special conditions

  • High pressure reactions (up to 200 bar)
  • Large scale hydrogenation
  • Large scale reactions (up to 30 L)
  • Large scale purification

• Scale up

See Also:

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Chemistry on Demand
Medicinal Chemistry
Screening Libraries
Additional Chemistry Services